3hub download12/31/2023 ![]() 8.3.8.3.1 How do I upload new software into the Linn DS/DSM.8.3.8.2 Can the DS player play multi-channel files?.8.3.8.1 Does the Linn DS/DSM players play MQA?.8.3.8 I cannot get any foreign Radio stations, I can only get UK stations.8.3.7 How do I add BBC Radio stations to my Presets?.8.3.6 Does the Linn DS/DSM players play BBC Radio via TuneIn?.8.3.5 I can no longer get Linn radio stream, Linn Jazz, Linn Classical, Linn Radio, station.8.3.4 Can I change the audio quality of the Tunein Radio.8.3.3.2.3 Can the Linn DS/DSM play DSD music?.8.3.3.2.2 Why does Linn recommend FLAC?.8.3.3.2.1 What audio formats do the DS players support?.8.3.3.1 To update, using an IR handset, and your current Linn DS/DSM is Davaar 99 or higher.8.3.2 Linn Ds/DSM software updates using Linn App.8.3.1.2.1 To update/recover, using Linn App, and your current Linn DS/DSM is Davaar 99 or higher.8.3.1.1.1 To update, using Konfig and your current Linn DS/DSM firm is Davaar 97 or lower.8.3.1 How do I Update, or recover, the software on a Linn DS/DSM.8.1.5.3 Can I plug my USB drive/stick into the USB socket to play Music.8.1.5.2 How to get my Alexa to Play on the Klimax DSM.8.1.5.1 What is the difference between Klimax DSM (2020 variant) and earlier versions?.8.1.4.2 How do I RECOVER on the Klimax DSM?.8.1.4.1 How do I do a FACTORY reset on the Klimax DSM?.8.1.3.1 How do I find the IP address of my Klimax DSM?.8.1.2.7 What does the shimmering dial mean?.8.1.2.6 Is it normal that the Klimax DSM display cannot always stay on? Can I adjust the display timeout?.8.1.2.5 Display is showing this icon beside the Volume indicator.8.1.2.4 I get a flashing Linn icon on the volume dial, what does this mean?.8.1.2.3 My Klimax DSM has a RED Linn symbol on the dial, what does this mean?.8.1.2.2 I get a flashing volume bars on the volume dial, what does this mean?.8.1.2.1 Putting my hand towards the Klimax DSM is not waking up the display, why not?.8.1.1.6 Is there a DIGITAL/SPDIF output?.8.1.1.5 How can I play my Computer Music on the Klimax DSM?.8.1.1.4 Can I plug a USB stick into the USB socket of the Klimax DSM.8.1.1.3 Is there a TAPE OUT on the Klimax DSM?.8.1.1.2 How can I connect my headphones to the Klimax DSM?.8.1.1.1 Can I use both the RCA and XLR outputs at the same time?.8.1 Linn Klimax DSM (2021 variant) FAQs.7.1 General products manuals and information.3.3.2 Using the Linn DS/DSM control software.3.3 Control of the Linn DS/DSM using a PC/MAC/Tablets & Phones.3.2 Controlling your Linn DS/DSM using and infrared handset.2.7.5 Can I use "Linn Account Space Optimisation" with my Exakt system?.2.7.4 Why don't you use a Microphone in Space Optimisation?.2.7.3 Is the Linn Account Manage systems only available for the new Linn DSM's.2.7.2 What is the difference between Space Optimisation & Space Optimisation+?.2.7.1 What are the differences between the Konfig Space Optimisation and Linn Account (Kloud Konfig) Space Optimisation?.2.6.2 Alternative Wifi Setup Method via Web Browser.2.6.1.3 Setting up Bluetooth or Wifi using the Klimax dial.2.6.1.2 Setting up Wifi using the Pin buttons. ![]() 2.6.1.1 Setting up Bluetooth using the Pin buttons.2.5.2 Using the Linn DS/DSM control software.2.5 Control of the Linn DS/DSM using a PC/MAC/Tablets & Phones.Exploiting this hotspot information allowed a peptide-based molecular glue that elicits high cooperativity ( α = 36) and selectively stabilizes the 14-3-3/ChREBP PPI to be uniquely developed. In addition to the phospho-binding pocket (i) Asn226, (ii) Lys122 and (iii) the hydrophobic patch formed by Leu218, Ile219 and Leu222 were critical for protein complex formation. Three central 14-3-3 hotspots were identified and their thermodynamic characteristics profiled. Truncation and mutation studies allowed deconvoluting the energetic contributions of sidechain and backbone interactions of a 14-3-3-binding non-natural peptide. Utilizing the hub protein 14-3-3 as a case study we demonstrate that functional mapping of hotspots provides a triage map for 14-3-3 molecular glue development. The functional mapping of hotspots has been critical to protein–protein interaction (PPI) inhibitor research, however, the orthogonal approach to stabilize PPIs has not exploited this information. Molecular glues represent an evolution in drug discovery, however, targeted stabilization of protein complexes remains challenging, owing to a paucity of drug design rules. ![]()
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